THE PROGNOSTIC SIGNIFICANCE OF BIOMARKERS FOR THE IMBALANCE BETWEEN ENERGY AND PLASTIC POTENTIALS FOR LEARNING THE MECHANISM OF DEVELOPMENT OF HEPATIC ENCEPHALOPATHY IN CHRONIC VIRAL HEPATITIS C

  • I.Yu. Bagmut Kharkiv Medical Academy of Postgraduate Education
  • S.M. Gramatiuk Kharkiv Medical Academy of Postgraduate Education
Keywords: hepatic encephalopathy, viral hepatitis C, plastic potential

Abstract

We examined 73 patients with chronic viral hepatitis C who underwent a routine examination at the Medical Diagnostic Center ASK-Health in Kharkiv. All patients underwent virus genetyping, 3 genotypes of HCV-infection were detected: 3a genotype was diagnosed in 13 patients, 2 genotypes – in 11, the largest group was made up of patients with 1b genotype of the virus - 49. The control group included 20 practically healthy persons who did not have the history of liver disease. The activity of glyceraldehyde-3-phosphate dehydrogenase in lymphocytes of patients with chronic viral hepatitis C and the phenomena of hepatic encephalopathy (n = 11) is reliably (p≤0.01) higher - by 2.3 times - as compared with the control group. Establishing a change in the metabolism of phosphotriose in blood cells probably suggests the predominant use of phosphotriose and neuron-specific enolase for energy metabolism and ATP production, that is, it is possible to assume that there is an imbalance between the energy and plastic potentials in the blood cells of patients with chronic viral hepatitis C, especially in erythrocytes.

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Published
2017-12-26
How to Cite
Bagmut, I., & Gramatiuk, S. (2017). THE PROGNOSTIC SIGNIFICANCE OF BIOMARKERS FOR THE IMBALANCE BETWEEN ENERGY AND PLASTIC POTENTIALS FOR LEARNING THE MECHANISM OF DEVELOPMENT OF HEPATIC ENCEPHALOPATHY IN CHRONIC VIRAL HEPATITIS C. The Medical and Ecological Problems, 21(5-6), 19-22. Retrieved from https://ecomed-journal.org/index.php/journal/article/view/96