• A.V. Loburets Higher State Educational Establishment of Ukraine "Ukrainian Medical Stomatological Academy",
  • K.S. Neporada Higher State Educational Establishment of Ukraine "Ukrainian Medical Stomatological Academy",
  • S.B. Bezshapochniy Higher State Educational Establishment of Ukraine "Ukrainian Medical Stomatological Academy",
Keywords: frontal sinus, sodium hyaluronate, hyaluronic acid, chronic sinusitis


Topicality: result of surgical treatment depends on the chosen method of postoperative period and the main role is the decrease of consequences of surgical trauma. Despite the wide range of drugs for local and systemic use the question of pharmacotherapy of operated sinus has not been decided yet. Safety and high clinical efficacy are the main peculiarities of modern drug. Recently doctors are interested in the use of drugs with hyaluronic acid. The aim is to investigate the clinical efficiency of drugs with hyaluronic acid in the treatment of chronic frontal sinusitis. Materials and Methods: Surgical treatment of 30 patients with chronic frontal sinusitis was done. Patients were divided into 2 groups based on postoperative period: I (n = 15) had traditional therapy with added hyaluronic acid medicines; II group (n = 15) of patients received traditional therapy that it included nasal cleaning, short course of local decongestants and aqueous salt solutions. For the evaluation of inflammatory-reduction processes in the frontal sinus obtained by washing with saline sodium chloride frontal sinus intraoperatively and then on the fifth day after surgery, proteinase-inhibitory potential, oxidative stress and hexuronic acid content were investigated. Results and discussion: medicines with sodium hyaluronate contribute to the inhibition of oxidative stress in flushing frontal sinus patients with chronic frontal sinusitis, as indicated by a significant decrease of а thiobarbituric acid (TBA-reagents), content of oxidatively modified proteins and the mean mass molecules against the growing activity of catalase and total antitryptic activity than these intraoperational indices and indicators in patients with conventional therapy. Conclusions: based on results of imvestigations it can be recommended the use of gel with sodium hyaluronate for pharmacorrection intraoperatively and during postoperative period to patients who took rhinisurgeries as effective anti-inflammatory and wound-healing agent.


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How to Cite
Loburets, A., Neporada, K., & Bezshapochniy, S. (2017). THE USE OF DRUGS WITH SODIUM HYALURONATE IN COMPLEX TREATMENT OF PATIENTS WITH CHRONIC FRONTAL SINUSITIS. The Medical and Ecological Problems, 21(1-2), 9-13. Retrieved from