• O.O. Piddubna HSEEU «Ukrainian Medical Stomatological Academy», Poltava, Ukraine
  • N.V. Lytvynenko HSEEU «Ukrainian Medical Stomatological Academy», Poltava, Ukraine
Keywords: hemoblastosis, quality of life, Impairment of the nervous system


Neurological disorders in oncohematologic diseases are among the secondary impairment of the nervous system and combine pathological conditions of the nervous system with different mechanisms of development and localization associated with neoplastic diseases of the blood system, which significantly exacerbates the course of the basic disease. The study of quality of life (QOL) in medicine provides information about the state of physical, emotional and psychological functioning of patient, allows to examine the dynamics of the disease and to evaluate the effectiveness of treatment. We investigated quality of life in patients with hemoblastosis and syndromologic features of the nervous system impairment. To accomplish this aim we conducted a complex of clinical and neurological examination with research of QOL by the questionnaire SF-36 in 77 patients with hemoblastosis. Depending on the type of underlying disease, patients were divided into 3 groups: patients with chronic lymphocytic leukemia (27 persons), patients with multiple myeloma (24 people) and patients with chronic myeloid leukemia (26 people). Control group consisted of 23 patients with appropriate age and gender allocation. According to the results of research, a significant decrease in all indicators of questionnaire SF-36 has been revealed in patients with hemoblastosis and impairment of the nervous system as compared to the control group. Impairment of the nervous system in patients with hemoblastosis was due to the influence of various aggregate factors, one of which can be regarded as lesion of the central and peripheral nervous system.


Download data is not yet available.


1. Poddubnaya I.V. Nehodzhkinskie limfomyi. Klinicheskaya onkogematologiya: rukovodstvo dlya vrachey / I.V. Poddubnaya– Moskva: Meditsina, 2007. – 724-711 s.
2. Gluzman D.F. Opuholi krovetvornoy i limfoidnoy tkaney (tsitomorfologiya, immunotsitohimiya, algoritmyi diagnostiki) / D.F. Gluzman, L.M. Sklyarenko, V.A. Nadgornaya.- Kiev: DIA, 2008.- 196 c.
3. Novik A.A. Kontseptsiya issledovaniya kachestva zhizni v meditsine / A.A. Novik, T.I. Ionova, P. Kaynd.- Sankt-Peterburg, 2006.- 140 c.
4. Anderson R.T. Critical review of the international assessment of health-related quality of life / R.T. Anderson, N.K. Aaronson, D. Wilkin. – New York: Qual. Life Res, 2003. – 369-395 p.
5. ASCO. Outcomes of cancer treatment for technology assessment and cancer treatment guidelines: journ. in 14 v. V. 3 / J. Clin. Oncol., 2006. - 671-679 p.
6. Novik A.A. Otsenka kachestva zhizni bolnogo v meditsine / A.A. Novik, S.A. Matveev, T.I. Ionova. – Sankt-Peterburg: Klin. med., 2000. - 10 c.
7. Problemyi izucheniya kachestva zhizni v sovremennoy meditsine: [nauch. obzor] / pod red. Orlova V.A. i dr. – Moskva: Seriya: Meditsina i zdravoohranenie, 2002. - 66 s.
8. Efficace F. GIMEMA and EORTC Quality of Life Group. Time for a new era in the evaluation of targeted therapies for patients with chronic myeloid leukemia: Inclusion of quality of life and other patient-reported outcomes / F.Efficace, K. Cocks, M. Breccia et al. // Crit. Rev. Oncol. Hematol. – 2012.- №2. – p. 123-35.
9. Bevans M.F. Function, Adjustment, Quality of Life and Symptoms (FAQS) in Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) Survivors: A Study Protocol / M.F. Bevans, S.A. Mitchell, A.J. Barrett et al. // Health and Quality of Life Outcomes. - 2011. - №9, - p.176.
10. Biostatistika : [pidruch. dlya stud.] / V.F. Moskalenko, O.P. GulchIy, M.V. Golubchikov, B.O LEdoschuk. – KiYiv : Kniga plyus, 2009. – 184 s.
11. Pathology and genetics of tumors of haematopoetic and lymphoid tissues / E.S. Jaffe, N.L. Haris, H. Stein, Y.W. Vardiman. - Lyon: IARC Press, 2001. - 351 p.
How to Cite
Piddubna, O., & Lytvynenko, N. (2017). QUALITY OF LIFE ASSESSMENT IN PATIENTS WITH HEMOBLASTOSIS WITH IMPAIRMENT OF NERVOUS SYSTEM. The Medical and Ecological Problems, 20(1-2), 13-15. Retrieved from https://ecomed-journal.org/index.php/journal/article/view/4