ADVERSE EFFECTS OF LAPROL-604 ON PREGNANT WISTAR RATS

  • T.M. Popova Kharkiv Medical Academy of Postgraduate Education
Keywords: Laprol-604, polyols, surfactant, reproductive toxicity, pregnant rat, gestation day, liver weight, food consumption, water intake

Abstract

The article reports the results of research Laprol-604-induced effects on general weight, liver weight of pregnant rats, and their food and water consumption. Pregnant Wistar rats were administered 0,125; 1,25 and 12,5 mg/kg Laprol-604 once daily by gavage from the second gestation day (GD) to the twentieth GD. Maternal toxicity of Laprol-604 indicated by deficits in weight gain, reduction of food consumption, increase in drinking regimen and largamente of liver weight were observed in 1-rst, 2-nd and 3-rd groups, during pregnancy. The severity Laprol-604 induced effects were dose-dependent. The lag in weight gain was particularly pronounced in the pregnant rats of the 2nd and 3-rd groups. Pregnant rats in the 2nd (1,25mg/kg) and 3-rd (12,5 mg/kg) groups failed to gain any weight until the last week of pregnancy. These weight gain deficits corresponded to significant reductions in food consumption throughout gestation. Liver weights of the Laprol-604 -exposed pregnant rats, except 1-rd group, were different from controls appreciably. It should be noted, while body weight was deficit, the relative liver weight of all Laprol-604 dosage groups was significantly increased.

Downloads

Download data is not yet available.

References

1. Bailey, S.A., Zidell, R.H. and Perry, R.W. (2004) Relationships between Organ Weight and Body/Brain Weight in the Rat: What Is the Best Analytical Endpoint? Toxicologic Pathology, 32, 448-466.
2. Buelke-Sam, J., Nelson, C. J., Byrd, R. A., and Holson, J. F. (1982) Blood flow during pregnancy in the rat: I. Flow patterns to maternal organs. Teratology 26: 269–277
3. Council of Europe [France]. European convention for the protection of vertebrate animals used for experimental and other scientific purposes. Strasbourg,18.III.1986, http://conventions.coe.int/treaty/en/Treaties/Word/123.doc
4. Lara-Martin PA, Gomez-Parra A, and Gonzalez-Mazo E (2008) Sources, transport and reactivity of anionic and non-ionic surfactants in several aquatic ecosystems in SW Spain: a comparative study. Environmental Pollution 156 (1): 36–45
5. Martin-Pont B, Tamboise E. (1984) Study of the weight of the pregnant rat and the maternal liver: their relation to biometric parameters of the developing embryo and placenta. Bull Assoc Anat (Nancy). 68(203):41-58.
6. Olkowska E, Ruman M, Kowalska A and Polkowska Z (2013) Determination of surfactants in environmental samples. Part III. Non-ionic compounds. Ecological Chemistry and Engineering S 20 (3): 449–461
7. Petrovic M, Fernández-Alba AR, Borrull F et al (2002) Occurrence and distribution of nonionic surfactants, their degradation products, and linear alkylbenzene sulfonates in coastal waters and sediments in Spain. Environmental Toxicology and Chemistry 21(1): 37–46
8. Ramesh C Gupta (2011) Reproductive and Developmental Toxicology. Academic press ELSEVIER: 1223
9. RezunenkoYu, Zhukov V, Kucheriavchenko M et all (2015) The effect of Laproxide L-303 on some hormonal exchange indices in prolonged toxification of white rats J Clin Exp Med Res 3(1): 44-50 [in Russian]
10. Scherban NG, Zhukov VI, Kapustnik VA et all (2013) Medical toxicological investigation of superficially active substances in connection with the problem of sanitary protection of drinking water sources. International Medical Journal 2: 116-120 [in Russian]
11. Ying G G (2006) Fate, behavior and effects of surfactants and their degradation products in the environment Environ. Int. 32 (3): 417-431
12. Yuan C L, Xu Z Z, Fan M X et al (2014) Study on characteristics and harm of surfactants Journal of Chemical and Pharmaceutical Research 6(7): 2233-2237
13. Zhukov V., Telegin V., Zaytseva O. et all (2013) Toxicologic and hygienic haracteristics of P-373-2-20; P-5003-AC; P-294-2-35 polyols an prognosis of their potential danger to environment Science Research 1(2): 31-34
14. Zhukov V.I. (2000) Environmentally-hygienically description of superficially-active substances as contaminants of reservoirs. Kharkov: Tornado:180 [in Russian].
Published
2017-03-21
How to Cite
Popova, T. (2017). ADVERSE EFFECTS OF LAPROL-604 ON PREGNANT WISTAR RATS. The Medical and Ecological Problems, 20(5-6), 43-46. Retrieved from https://ecomed-journal.org/index.php/journal/article/view/30