CONDITION OF ANTIOXIDANT ACTIVITY OF THE LIVER IN RATS UNDER THE INFLUENCE OF SMALL DOSES OF SODIUM FLUORIDE
Keywords:
free radical processes, sodium fluoride, liver rats
Abstract
The effect of small subtoxic doses of sodium fluoride on the antioxidant activity of the liver has been studied in Wistar rats populations in the subacute experiment. The intensity of lipid peroxidation was estimated by the content of its molecular products − diene conjugates (DC), and TBA-reagents and schiff bases in liver homogenate of rats (N = 30) which were ad-ministered small subtoxic doses of sodium fluoride. It has been found that oral administration of sodium fluoride in rats at doses of 1/10 and 1/100 LD50 promotes diene conjugates content in all periods of observation. In rat liver, starting from the 20th day, the gradual increase of TBA-reagents and schiff bases was clearly defined. Enhanced CL intensity estimates by 37 and 134% was detected in the case of sodium fluoride action at a dose 1/10 LD50, respectively.
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References
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Published
2017-03-21
How to Cite
Kolisnyk, I. (2017). CONDITION OF ANTIOXIDANT ACTIVITY OF THE LIVER IN RATS UNDER THE INFLUENCE OF SMALL DOSES OF SODIUM FLUORIDE. The Medical and Ecological Problems, 20(5-6), 37-42. Retrieved from https://ecomed-journal.org/index.php/journal/article/view/29
Section
EXPERIMENTAL MEDICINE
