COMPARISON OF CONSERVATIVE METHODS OF PREVENTION OF PATHOLOGICAL SCARING OF THE HEAD AND NECK

Keywords: wound healing, head and neck scars, conservative prevention, prevention of scar formation, pathological scars

Abstract

Wound healing is one of the most common and complex processes, which includes five phases: hemostasis, inflammation, proliferation, re-epithelialization, and remodeling. Each stage of wound healing requires the complex synchronization and regulation of multiple cell populations. Violation of the link of any of these processes can lead to the appearance of complications and increase the likelihood of the formation of pathological scars. To study the research materials, we used the bibliosemantic and analytical method, with the help of which we processed the literary data, as well as the materials of clinical studies, which were posted on the Internet. There are many conservative methods of prevention of the pathological scars formation in the area of head and neck, one of the main links is occupied by ointments with different components. Thus, a clinical study by Marquardt Y showed that the local application of dexpanthenol in the form of an ointment contributes to better healing of superficial and postoperative wounds. According to foreign scientists, silicone products, both in the form of sheets and gel, are considered to be the first line in the prevention and treatment of hypertrophic and keloid scars. Goutos I., suggested the use of corticosteroid tape, which is a painless alternative to corticosteroid injections. Japanese scientists Ogawa R and co-authors note the good clinical experience and results of using corticosteroid tape and patch. Recent research by Powell HM., 2022 on the use of pressure therapy for lacerations has shown that tension relief is a powerful strategy to prevent scar formation in the head and neck area. Ud-Din S et al., proposed photodynamic therapy, which has a good evidence base for the effectiveness of this method. Over the past decade, many high-quality studies have been conducted, increasing the level of evidence base for many prevention or treatment regimens. The article reflects modern methods of conservative prevention, however, taking into account ethnic differences, predisposition to pathological scars, algorithms for prevention and treatment should be refined and optimized.

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References

Wang ZC, Zhao WY, Cao Y, et al. The Roles of Inflammation in Keloid and Hypertrophic Scars. Front Immunol. 2020;11:603187. Published 2020 Dec 4. doi:10.3389/fimmu.2020.603187.

White T. The physiology of wound healing: Injury through maturation. Perioperative Nurs Clinics (2009) 6(2):159–70. doi: 10.1016/j.suc.2009.03.006.

Smandri A, Nordin A, Hwei NM, Chin KY, et al. Natural 3D-printed bioinks for skin regeneration and wound healing: A systematic review. Polymers (Basel) (2020) 12(8):1782. doi: 10.3390/polym12081782.

Honrado CP, Murakami CS. Wound healing and physiology of skin flaps. Facial Plast Surg Clinics North America (2005) 13(2):203–14. doi: 10.1016/j.fsc.2004.11.007.

Wilgus TA, Roy S, McDaniel JC. Neutrophils and wound repair: Positive actions and negative reactions. Adv Wound Care (New Rochelle) (2013) 2(7):379–88. doi: 10.1089/wound.2012.0383.

Kloc M, Ghobrial RM, Wosik J, Lewicka A, et al. Macrophage functions in wound healing. J Tissue Eng Regener Med (2019) 13 (1):99–109. doi: 10.1002/term.2772.

7.Krzyszczyk P, Schloss R, Palmer A, Berthiaume F. The role of macrophages in acute and chronic wound healing and interventions to promote pro-wound healing phenotypes. Front Physiol (2018) 9. doi: 10.3389/fphys.2018.00419.

Li M, Hou Q, Zhong L, Zhao Y, et al. Macrophage related chronic inflammation in non-healing wounds. Front Immunol (2021) 12:681710. doi: 10.3389/fimmu.2021.681710.

Marconi GD, Fonticoli L, Rajan TS, Pierdomenico SD, et al. Epithelial-mesenchymal transition (EMT): The type-2 EMT in wound healing, tissue regeneration and organ fibrosis. Cells (2021) 10(7):1587. doi: 10.3390/cells10071587.

Wilkinson HN, Hardman MJ. Wound healing: cellular mechanisms and pathological outcomes. Open Biol (2020) 10(9):200223. doi: 10.1098/rsob.200223.

Ogawa R. Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis. Int J Mol Sci (2017) 18:606. 10.3390/ijms18030606.

Huang C, Akaishi S, Hyakusoku H, Ogawa R. Are keloid and hypertrophic scar different forms of the same disorder? A fibroproliferative skin disorder hypothesis based on keloid findings. Int Wound J (2014) 11:517–22. 10.1111/j.1742-481X.2012.01118.x.

Amici JM, Taïeb C, LeFloc'h C, Demessant-Flavigny AL, et al. Prevalence of scars: an international epidemiological survey in adults. J Eur Acad Dermatol Venereol. 2022 Oct;36(10):e799-e800. doi: 10.1111/jdv.18277. Epub 2022 Jun 7. PMID: 35633084; PMCID: PMC9544440.

Heise R, Schmitt L, Huth L, Krings L, et al. Accelerated wound healing with a dexpanthenol-containing ointment after fractional ablative CO2 laser resurfacing of photo-damaged skin in a randomized prospective clinical trial. Cutan. Ocul. Toxicol. 2019;38:274–278. doi: 10.1080/15569527.2019.1597879.

Sobec RL, Fodor L, Bodog F. Topical Oxandrolone Reduces Ear Hypertrophic Scar Formation in Rabbits. Plast Reconstr Surg. 2019;143(2):481-487. doi:10.1097/PRS.0000000000005275.

Marquardt Y, Amann PM, Heise R, et al. Characterization of a novel standardized human three-dimensional skin wound healing model using non-sequential fractional ultrapulsed CO2 laser treatments. Lasers Surg Med. 2015;47(3):257-265. doi:10.1002/lsm.22341.

Baron J.M., Glatz M., Proksch E. Optimal support of wound healing: New insights. Dermatology. 2020:1–8. doi: 10.1159/000505291.

De Decker I, Hoeksema H, Verbelen J, et al. The use of fluid silicone gels in the prevention and treatment of hypertrophic scars: a systematic review and meta-analysis. Burns. 2022;48(3):491-509. doi:10.1016/j.burns.2022.03.004

Berman B, Perez OA, Konda S, et al. A review of the biologic effects, clinical efficacy, and safety of silicone elastomer sheeting for hypertrophic and keloid scar treatment and management. Dermatol Surg 2007; 33:1291–1302.

Bleasdale B, Finnegan S, Murray K, et al. The use of silicone adhesives for scar reduction. Adv Wound Care 2015;4:422-430.

Kalasho BD, Kikuchi R, Zoumalan CI. Silicone-Based Scar Cream for Post Upper Eyelid Blepharoplasty-associated Cicatricial and Hypertrophic Scarring. J Drugs Dermatol. 2019;18(5):440-446.

Del Toro, Drew, Dedhia, Raj et al. Advances in scar management. Current Opinion in Otolaryngology & Head and Neck Surgery. 2016; 24(4): 322–329. doi:10.1097/moo.0000000000000268.

Goutos I, Ogawa R. Steroid tape: A promising adjunct to scar management. Scars Burn Heal. 2017;3:2059513117690937.

Ogawa R, Akita S, Akaishi S, et al. Diagnosis and treatment of keloids and hypertrophic scars: Japan Scar Workshop Consensus Document 2018. Burns Trauma 2019;7:39.

Powell HM, Nedelec B. Mechanomodulation of Burn Scarring Via Pressure Therapy. Adv Wound Care (New Rochelle). 2022;11(4):179-191. doi:10.1089/wound.2021.0061.

Ud-Din S, Thomas G, Morris J, Bayat A. Photodynamic therapy: an innovative approach to the treatment of keloid disease evaluated using subjective and objective non-invasive tools. Arch Dermatol Res 2013;305(03):205–214.

Sakamoto FH, Izikson L, Tannous Z, Zurakowski D, et al. Surgical scar remodelling after photodynamic therapy using aminolaevulinic acid or its methyl ester: a retrospective, blinded study of patients with field cancerization. Br J Dermatol 2012; 166(02):413–416.

Mankowski P, Kanevsky J, Tomlinson J, Dyachenko A, et al. Optimizing radiotherapy for keloids: a meta-analysis systematic review comparing recurrence rates between different radiation modalities. Ann Plast Surg 2017;78(04):403–411.

Published
2022-12-29
How to Cite
Nahirniy, Y. P. (2022). COMPARISON OF CONSERVATIVE METHODS OF PREVENTION OF PATHOLOGICAL SCARING OF THE HEAD AND NECK. The Medical and Ecological Problems, 26(5-6), 52-55. https://doi.org/10.31718/mep.2022.26.5-6.10