ПЕРЕБІГ ГОСТРОЇ РЕСПІРАТОРНОЇ ХВОРОБИ COVID-19 УСКЛАДНЕНОЇ НЕГОСПІТАЛЬНОЮ ПНЕВМОНІЄЮ НА ТЛІ ПАТОЛОГІЇ СЕРЦЕВО-СУДИННОЮ СИСТЕМИ

  • Т.А. Трибрат Полтавський державний медичний університет, Полтава, Україна
  • Ю.М. Казаков Полтавський державний медичний університет, Полтава, Україна
  • О.О. Гончарова Полтавський державний медичний університет, Полтава, Україна
  • С.В. Шуть Полтавський державний медичний університет, Полтава, Україна
  • В.Д. Сакевич Полтавський державний медичний університет, Полтава, Україна
Keywords: course, acute respiratory COVID-19 disease, complications, community-acquired pneumonia, comorbidity, pathology of the cardiovascular system.

Abstract

The outbreak of the COVID-19 infection caused by the new coronavirus SARS-CoV-2 is one of the most significant and dangerous challenges of our time. To date, there is a decrease in the number of cases per day, but there is a variety in the course of the disease depending on sex, and the most vulnerable are elderly patients with comorbid pathology, therefore, the study of its features determines the relevance of this work. The aim of the research was to study the course of acute respiratory disease COVID-19, complicated by pneumonia, its gender features and the presence of a comorbid cardiovascular pathology. We examined 104 patients with acute respiratory COVID-19 disease, complicated by community-acquired pneumonia. We conducted general clinical methods of research, determined the SARS-CoV-2 virus RNA by PCR and chest X-ray in 2 projections or computed tomography (CT) to identify the features of the lung tissue damage. Among the cardiovascular pathology (35%) we observed coronary heart disease: stable angina pectoris FC (functional class) II-III - 85%, postinfarction cardiosclerosis - 30%, hypertension - 65%. Thus, a more pronounced intoxication syndrome of the variety of symptoms among women with acute respiratory COVID-19 disease, complicated by community-acquired pneumonia, is observed in women than in men, which must be taken into account, both in the diagnosis and treatment, assessment of prognosis of the development of the disease.

The presence of a comorbid pathology of the cardiovascular system complicated the course of the underlying disease. It had a more pronounced clinical course in a combination of two or more diseases and was characterized by progressive arrhythmias, subendocardial myocardial ischemia, volume overload of the left and right ventricles. A combination of several comorbid conditions was the most unfavorable for a patient, since it increased the risk of community-acquired pneumonia, was accompanied by its severe course with the development of complications and lethal outcome.

Downloads

Download data is not yet available.

References

1. Joshua P Metlay, Grant W Waterer. Treatment of Community-Acquired Pneumonia During the Coronavirus Disease 2019 (COVID-19) Pandemic. Ideas and Opinions. 2020;7. doi: https://doi.org/10.7326/M20-2189
2. Nazario B. Coronavirus and Pneumonia. WebMD Medical Reference. [Internet]; 2020 [cited 2020 Aug 21]. Available from: https://www.webmd.com/lung/covid-andpneumonia#1
3. Rong-Hui Du, Li-Rong Liang, Cheng-Qing Yang, Wen Wang, et al. Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study. Eur Respir J. 2020;55(5):2000524. doi: https://doi.org/10.1183/13993003.00524-2020
4. Chalmers J. D. Community-acquired pneumonia. Eur Respir Monog.2014;63: 289 p.
5. Garsia-Vidal C., Carratala J., Fernandez-Sabe N., Dorca J, Verdaguer R, Manresa F. Aetiology of, and risk factors for, recurrent community-acquired pneumoni.Clin. Microbiol. Infect. 2009;15:1033-1038.
6. SinganayagamA. , SinganayagamA. , ElderD.H.J. , ChalmerssJ.D. Сommunity-acquired pneumonia an independent risk factor for cardiovascular disease? Eur. Respir. J. 2012;39 :187-196.
7. Dandachi D. Rodriguez-Barradas M. C. Viral pneumonia: etiologies and treatment. Journal of Investigative Medicine. 2018;66:957-965. DOI: http://dx.doi.org/10.1136/jim-2018-000712
8. Cilloniz C, Martin-Loeches I, Garcia-Vidal C, San Jose A, Torres A. Microbial Etiology of Pneumonia: Epidemiology, Diagnosis and Resistance Patterns. Int J Mol Sci. 2016;17(12):2120.
9. Goldblatt D., Miller E. Pneumococcal pneumonia. Thorax. 202;.75(1) :6-7. DOI: https://doi.org/10.1136/thoraxjnl-2019-214135
https://doi.org/10.3390/ijms17122120
10. Adaptovana klinichna nastanova, zasnovana na dokazakh «Nehospitalʹna pnevmoniya u doroslykh osib: etiolohiya, patohenez, klasyfikatsiya, diahnostyka, antymikrobna terapiya ta profilaktyka». Vyd. ofits. YU. I. Feshchenko ta in. Nats. akademiya medychnykh nauk, Kyyiv. 2019; 94 s.
11. Metlay Joshua P, Waterer Grant W, Long Ann C, Anzueto Antonio, Brozek Jan, Crothers Kristina. Diagnosis and Treatment of Adults with Community-acquired Pneumonia: An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America .Am J Respir Crit Care Med. 2019;200(7):45-67.
12. Pertseva TO, Kiryeyeva TV, Byelosludtseva KO. Etiolohichni, klinichni ta patolohoanatomichni osoblyvosti nehospitalʹnoyi pnevmoniyi v epidemichnyy period. Ukr. pulʹmonol. zhurnal. 2016;3:15-20.
13. Burmak YuG, Petrov YeYe, Kazakov Yu M, Chekalina NI,Treumova S. I,Tribrat TA. The peculiarities of the changes of some cardiohemodynamic and microcirculatory indices in conditions of the comorbid course of essential hypertension. The New Armenian medical Journal. 2020; 14(2): 20–28.
14. Trybrat ТА, Shut’ SV, Borisova ZO,Sakevych VD, Goncharova OO.Some characteristics of course of coronary heart disease with comorbid pathology.The Medical and ecological problems. 2020;24(1-2)8-11.
15. Trybrat TA, Shutʹ SV, Trybrat AA, Kazakov YUM. Shlyakhy korektsiyi asotsiyovanoho metabolichnoho syndromu u khvorykh na hipertonichnu khvorobu Visnyk problem biolohiyi i medytsyny.2018; 1 (142):197–201.
16. Manusha YU I, Kazakov YUM, Chekalina NI. Trybrat T A. Vakulenko K YE. Klinichnyy perebih ishemichnoyi khvoroby sertsya v umovakh komorbidnosti z nealkoholʹnoyu zhyrovoyu khvoroboyu pechinky. Aktualʹni problemy suchasnoyi medytsyny. 2019; 19, 3 (67):52–56.
17. Petrov YеYе, Burmak YUH, Treumova SI, Ivanytsʹka TA. Porivnyalʹna kharakterystyka deyakykh pokaznykiv lipidnoho obminu i funktsiyi endoteliyu u khvorykh na kompensovane khronichne leheneve sertse bronkho-lehenevoho genezu ta v umovakh yoho komorbidnosti z hipertonichnoyu khvoroboyu. Visnyk problem biolohiyi i medytsyny.2020;1 (155):179–182.
18. Zminy do Standartiv medychnoyi dopomohy «Koronavirusna khvoroba (COVID19): zatv. Nakazom MOZ Ukrayiny vid 28.03.2020 r. № 722. Nakaz MOZ Ukrayiny vid 23.04.2020 r. № 953. URL: https://moz.gov.ua/uploads/4/20303- dn_20200423_953_dod.pdf
Published
2021-08-31
How to Cite
Трибрат, Т., Казаков, Ю., Гончарова, О., Шуть, С., & Сакевич, В. (2021). ПЕРЕБІГ ГОСТРОЇ РЕСПІРАТОРНОЇ ХВОРОБИ COVID-19 УСКЛАДНЕНОЇ НЕГОСПІТАЛЬНОЮ ПНЕВМОНІЄЮ НА ТЛІ ПАТОЛОГІЇ СЕРЦЕВО-СУДИННОЮ СИСТЕМИ. The Medical and Ecological Problems, 25(3-4), 14-17. https://doi.org/10.31718/mep.2021.25.3-4.03