• T.M. Popova Kharkiv Medical Academy of Postgraduate Education
Keywords: Laprol- 604, polyols, surfactant, modeling, rats, reproductive toxicity, developmental toxicity, gestation day, postnatal day


This article introduces the results of research the Laprol-604-induced effects on the prenatal and early postnatal development of the Wistar rats. The high production volumes and widespread use of surfactants have been an environmental concern since the early 1960s. Surfactants are used in industry and agriculture and are also found in household and personal care products. The presence of surfactants and their biodegradation products in different environmental compartments can invoke a negative effect on the biota [13]. The toxicity of surfactants to living organisms has been summarized in the scientific literature. Nevertheless, some information is still lacking in relation to the reproductive effects need to be understood in order to avoid unexpected adverse effects on future generations of people and the environment. Reproduction is a critical biological process of human and animal populations. It is known the embryo and fetus have immature blood–brain barrier, hepatic detoxifying, metabolizing properties and only rudimentary DNA repair mechanisms [17]. Therefore, the embryo and fetus are more vulnerable than adults to the adverse effects of xenobiotics such as surfactant exposures. This study has been performed to increase the understanding of the adverse reproductive effects associated with Laprol-604 animals exposed during embryonic, fetal, and early postnatal development. Pregnant Wistar rats were administered 0,125; 1,25 and 12,5 mg/kg Laprol-604 once daily by gavage from the second gestation day (GD) to the twenty first GD. Controls consisted of 25 intact pregnant Wistar rats without Laprol-604 administration. Time of parturition for each animal, number of live pups and their conditions have been examined. All of live pups were daily counted, tabulated and they have been weighed several times during postnatal period. All live pups have been born by rats exposed to Laprol-604 12,5 mg/kg were pallid, inactive and died within the first 48 hours after birth. Approximately 50% of the pups of pregnant rats administrated 1,25 mg/kg died during the first 10 days after birth. Other 50% of these animals survived and reached puberty, but they had significant growth retardation. The surviving young rats had significantly higher liver weight compared to the control animals. Survival has been improved by lower dosage Laprol-604 administration and over 80% pups exposed to 0,125 mg/kg Laprol-604 have been born alive, stayed active for postnatal life and reached puberty. The results of study indicated that exposure of Laprol-604 to the pregnant rats caused decreasing postnatal survival of neonates, stunted growth in the surviving rat pups.


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How to Cite
Popova, T. (2017). THE REPRODUCTIVE INFLUENCE OF LAPROL-604 ON WISTAR RATS. The Medical and Ecological Problems, 20(3-4), 28-32. Retrieved from