• I. P. Pashkovа Vinnitsa National Medical University named after. M. I. Pirogov
  • V.M. Zhebel Vinnitsa National Medical University named after. M. I. Pirogov
Keywords: essential hypertension, chronic heart failure, gene polymorphism of the brain natriuretic peptide, plasma concentration of brain natriuretic peptide, plasma concentration of endothelial natriuretic peptide


We investigated the organization of the brain natriuretic peptide gene (BNP T-381C) and plasma levels of BNP, CNP in male citizens of Podillia region in Ukraine with essential hypertension stage II and with its complications of chronic heart failure stage IIA. Genotyping of the BNP gene was conducted using polymerase chain reaction. The levels of BNP and CNP plasma concentrations were determined by ELISA. It was established that among practically healthy men and patients with essential hypertension of varying severity, the genotype Т381С and C allele of the BNP gene dominanted. The carriers of the C allele of the BNP gene have significantly higher plasma levels of brain and endothelial natriuretic peptides as against the control group and patients with essential hypertension. In addition, the highest levels of natriuretic peptides were determined in patients with symptoms of chronic heart failure stage IIA.


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1. Berezikova E.N. Gene polymorphism of brain natriuretic peptide in patients with chronic heart failure / E.N. Berezikova, S.D. Mayanskaya, L.A. Garayev [et al.] // Kazan Journal of Medicine. – 2013. - Vol. 4. – Р. 433-438.
2. Voronkov L.G. The way patients with chronic heart failure as long as possible as you can comfortably / L.G. Voronkov // Heart Failure. - 2014. – Vol. 1. - P. 7-10.
3. Sakovych О.О. Plasma concentrations of natriuretic peptides and endothelin-1 in postmenopausal women with essential hypertension of different severity / О.О. Sakovych, V.M. Zhebel // Family Medicine. - 2011. – Vol. 4. - P. 108-113.
4. Starzhynska О.L. Рolymorphism of the angiotensin II receptor gene in hypertensive patients of different stages as a factor of influence on the structure and function of the myocardium / V.M. Zhebel, О.L. Starzhynska, U.O. Hefter [et al.] // Hypertension. – 2009. – Vol. 1(3). - С. 24-29.
5. Ukraine Patent 67486, the IPC G01N 33/48 (2006.01). Method of diagnosis of chronic heart failure in women of postmenopausal age with hypertension / V.M. Zhebel, О.O. Sakovych, G.V. Wilczynskyy, O.O. Singh; the applicant and the owner the Vinnitsa National Piragov Memorial Medical University. - №u201108789; appl. 07/12/11; publ. 27.02.12, Bulletin of №4.
6. Antomonov M.Y. The calculation of thresholds (critical) action levels of accounting factors for different types of data obtained in hygienic Research / M.Y. Antamonov // Health of settlements. - 2004. - № 43. - Р. 573-579.
7. Berezin A. Utility of Biomarkers in Contemporary Management of Chronic Heart Failure / A. Berezin // Annals of Clinical and Laboratory Research, iMedPub Journals. - 2015. - Vol. 3(2). – P. 16-28.
8. Costello-Boerrigter L.C. The Effect of the Brain-Type Natriuretic Peptide Single-Nucleotide Polymorphism rs198389 on Test Characteristics of Common Assays / L.C. Costello-Boerrigter, G. Boerrigter, S. Ameenuddin [et al.] // Mayo Clin Procv. – 2011. – Vol. 86 (3). – P. 210-218.
9. Lajer M. Polymorphisms in the B-type natriuretic peptide (BNP) gene are associated with NT-proBNP levels but not with diabetic nephropathy or mortality in type 1 diabetic patients / M. Lajer, L. Tarnow, A. Jorsal [et al.] // Nephrol Dial Transplant. – 2007. – Vol. 22(11). – P. 3235-3239.
10. Lanfear D.E. Genetic variation in the B-type na-triuretic peptide pathway affects BNP levels / D.E. Lanfear, J.M. Stolker, S. Marsh [et al.] // Cardiovasc. Drugs Ther. - 2007. – Vol. 21. – P. 55– 62.
11. Lin Q. Copeptin in the assessment of acute lung injury and cardiogenic pulmonary edema / Q. Lin, F. Fu, H. Chen [et al.] // Respir. Med. - 2012. - Vol. 106(9). – Р. 1268-1277.
12. Meirhaeghe A. Association between the T-381C polymorphism of the brain natriuretic peptide gene and risk of type 2 diabetes in human populations / A. Meirhaeghe, M.S. Sandhu, M.I. Carthy // Hum Mol Genet. - 2007. - Vol. 16(11). – P. 1343-1350.
13. Nair N. Circulating miRNA as novel markers for diastolic dysfunction / N. Nair, S. Kumar , E. Gongora [et al.] // Mol Cell Biochem. – 2013. - Vol. 376(1-2). – Р. 33-40.
14. Ohtani T. Diastolic stiffness as assessed by diastolic wall strain is associated with adverse remodelling and poor outcomes in heart failure with preserved ejection fraction / T. Ohtani, S.F. Mohammed, K. Yamamoto [et al.] // Eur Heart J. – 2012. – Vol. 33. – Р. 1742-1749.
15. Pfister R. Mendelian Randomization Study of B-Type Natriuretic Peptide and Type 2 Diabetes: Evidence of Causal Association from Population Studies / R. Pfister, S. Sharp, R. Luben [et al.] // PLoS Medicine. – 2011. – Vol. 8(10). – P. 1-11.
16. Takeishi Y. Linkage disequilibrium analyses of natriuretic peptide precursor B locus reveal risk haplotype conferring high plasma BNP levels / Y. Takeishi, S. Toriyama, N. Takabatake [et al.] // Biochem Biophys Res Commun. – 2007. - Vol. 362. – Р. 480–484.
17. Volpe M. Natriuretic peptides and cardio-renal disease / M. Volpe // International Journal of Cardiology. – 2014. – Vol. 176(3). – P. 630–639.
How to Cite
PashkovаI. P., & Zhebel, V. (2017). ON THE GENETIC REGULATION OF BRAIN NATRIURETIC PEPTIDE LEVEL IN PLASMA OF MEN WITH ESSENTIAL HYPERTENSION. The Medical and Ecological Problems, 20(1-2), 6-9. Retrieved from https://ecomed-journal.org/index.php/journal/article/view/2