• T. M. Popova Kharkiv national medical university, Kharkiv, Ukraine
Keywords: Laprol-604, surfactant, reproductive toxicity, developmental toxicity, gestation day, postnatal day


The article introduces findings of the study on surfactant-induced effects on the growth and maturation of rat pups, prenatally exposed to Laprol-604. The adverse influence of Laprol-604 exposure on rat fetuses was identified in the immediate postnatal period (0-3 days) and later. Laprol-604 induced neonatal mortality within the period of three days, reduced litter size, resulted in low-birth-weight of progeny and a decrease in body weight gain in rat pups. Somatic growth retardation produced by Laprol-604 persisted during postnatal period and was accompanied by a delay in integumental morphogenesis of rat pups. Closer examination revealed an impact of Laprol-604 on delayed opening of the external auditory canal, resulting in an altered sequence of craniofacial development, such as the time of eyelid opening, incisor eruption.  Maternal Laprol-604 exposure adversely affected the release and erection of the pinna. In summary, Laprol-604 had dosage-dependent developmental toxicity effect on progeny of female rats exposed to Laprol-604 during gestational period.


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1. Bagmut I.Y. The influence of sub-toxic dose xenobiotic on immune response of experimental animals / I.Y.Bagmut, T.M. Popova, A.V. Titkova et al. // J of Education, Health and Sport. – 2016. –Vol. 6(11). – P. 629-639.
2. Bagmut I.U. Evaluation of subtoxic influence of phosphorus organic subtances on the male rat reproductive function during the subacute experiment/ Bagmut I.U., Zharova NV, Zhukov V.I., Tyupka T.I., Popova T.M. // Odessa Medical Journal. – 2016. –Vol. 6 (158). – P. 5-9.
3. Council of Europe [France]. European convention for the protection of vertebrate animals used for experimental and other scientific purposes. Strasbourg,18.III.1986, http://conventions.coe.int/treaty/en/Treaties/Word/123.doc
4. EPA (US Environmental Protection Agency) (1991) Guidelines for Developmental Toxicity Risk Assessment. Risk Assessment forum, US Environmental Protection Agency, Washington/DC. EPA/600/FR-91-001
5. Grasty R.C. (2003) Prenatal window of susceptibility to perfluorooctane sulfonate-induced neonatal mortality in the Sprague-Dawley rat/ Grasty R.C., Grey B.E., Lau C.S. et al // Birth Defect Res . – 2003. –Vol. 68. – P.465–471.
6. Lara-Martin P.A. Sources, transport and reactivity of anionic and non-ionic surfactants in several aquatic ecosystems in SW Spain: a comparative study/ Lara-Martin PA, Gomez-Parra A, and Gonzalez-Mazo E // Environmental Pollution . – 2008. –Vol. 156 (1). – P.36–45.
7. Popova T.M. The reproductive influence of Laprol-604 on wistar rats/ Popova T.M., Zharova NV, Kolesnik I.L. et al // Problems of environment and medicine . – 2015. –Vol. 19 (5/6). – P. 11-16.
8. Popova T.M. The typical pathochemical reactions of the damaging impact of detergents as sources of radiotoxins / Popova T.M., Zharova NV, Kolesnik I.L. et al // Problems of environment and medicine . – 2015. –Vol. 19 (5/6). – P. 11-16.
9. Ramesh C Gupta (2011) Reproductive and Developmental Toxicology. Academic press ELSEVIER: 1223
10. Zhukov VI (2000) Environmentally-hygienically description of superficially-active substances as contaminants of reservoirs. Kharkov Tornado:180 [in Russian].
11. Zhukov V., Telegin V., Zaytseva O. et all, Toxicologic and hygienic haracteristics of P-373-2-20; P-5003-AC; P-294-2-35 polyols an prognosis of their potential danger to environment: Science Research, 2013, 1(2): P. 31-34.
How to Cite
Popova, T. M. (2018). EVALUATION OF GROWTH AND DEVELOPMENT OF RAT PUPS, PRENATALLY EXPOSED TO LAPROL-604. The Medical and Ecological Problems, 22(5-6), 19-21. https://doi.org/10.31718/mep.2018.22.5-6.04