THE IFN-Α SYNTHESIS MONITORING ON LOCAL AND GENERAL LEVELS IN PATIENTS WITH HERPES SIMPLEX VIRUS INFECTION

  • N. M. Horbal Danylo Halytsky Lviv National Medical University
  • K. E. Ishcheykin Ukrainian medical stomatological academy
  • G. O. Potemkina Danylo Halytsky Lviv National Medical University
  • I. G. Gaiduchok Lviv Medical Institute
  • I. J. Kril Danylo Halytsky Lviv National Medical University
  • V. V. Chopyak Danylo Halytsky Lviv National Medical University
Keywords: herpes simplex infection, IFN-α, antiviral and immunotropic therapy

Abstract

This article presents the results of the investigation of IFN-α synthesis dynamics on local and general levels in patients with the recurrent simple herpesvirus infection. The influence of different types of antiviral therapy to IFN-α level is estimated as well. The normalization of IFN-α level was noted in the group of patients with simple herpesvirus infection after applying of antiviral therapy and three months after the treatment, especially in the group of patients with mild course of HSV 1/2 infection, that proves the antiviral defence stabilization. Moreover, the clinical efficacy of the proposed treatment was established for patients with the recurrent HSV 1/2 infection: in the group of patients with the mild course of HSV 1/2 infection it was 73.5% after the treatment and 85.8% in the remote period; in the group of patients with the mild and severe course of HSV 1/2 infection it was 64.0% after the treatment and 70.4% in the remote period.

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Published
2018-12-26
How to Cite
Horbal, N. M., Ishcheykin, K. E., Potemkina, G. O., Gaiduchok, I. G., Kril, I. J., & Chopyak, V. V. (2018). THE IFN-Α SYNTHESIS MONITORING ON LOCAL AND GENERAL LEVELS IN PATIENTS WITH HERPES SIMPLEX VIRUS INFECTION. The Medical and Ecological Problems, 22(5-6), 3-9. https://doi.org/10.31718/mep.2018.22.5-6.01