THE PATHOPHYSIOLOGICAL MECHANISMS OF ENDOGENOUS INTOXICATION IN PATIENTS WITH THYROID CANCER

  • I.Yu. Bagmut Kharkiv Medical Academy of Postgraduate Education, Ukraine
  • O.O. Galmiz Kharkiv Medical Academy of Postgraduate Education, Ukraine
  • S.М. Gramatiuk Kharkiv Medical Academy of Postgraduate Education, Ukraine
Keywords: average molecular peptides, lipid peroxidation products, oxidative modification of proteins, intoxication.

Abstract

In the present paper, the content of the average molecular peptides, lipid peroxidation products, oxidative modifications of proteins in the serum of patients with thyroid cancer has been studied and their prognostic value has been substantiated in optimizing of pathogenic therapy. The study involved 94 patients who were divided into 3 groups depending on the cell structure of the tumor. The results of the study revealed the increase in serum levels of malonic dialdehyde, dienes, 2,4-dinitrophenylaldo-hydrazones and 2,4-dinitrophenylketohydrugs, low molecular weight molecules and leukocyte intoxication index. It is established that the leading pathogenic mechanism of formation and decompensation of endotoxicosis in thyroid cancer patients is the accumulation of the ratio of plasma and erythrocyte fraction of substances of low and average molecular weight of plasma and red blood cells, especially their large-molecular, catabolic fraction, with violation of renal excretion of endotoxins.

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Published
2018-03-20
How to Cite
Bagmut, I., Galmiz, O., & Gramatiuk, S. (2018). THE PATHOPHYSIOLOGICAL MECHANISMS OF ENDOGENOUS INTOXICATION IN PATIENTS WITH THYROID CANCER. The Medical and Ecological Problems, 22(1-2), 53-56. https://doi.org/10.31718/mep.2018.22.1-2.11