• O.V. Movchan Kharkiv Medical Academy of Postgraduate Education
  • A.V. Titkova Department of Clinical Pathophysiology, Topographic Anatomy and Surgical Surgery Kharkov, Ukraine
Keywords: microsatellite instability, inability of seams of anastomosis, microbiocynosis.


It should be recognized that the creation of optimal conditions for healing of intestinal sutures is the main reserve for improving the results of surgical intervention on the organs of the gastrointestinal tract. The urgent issues of pathophysiology associated with oncopathology remain the inability of seams of anastomosis and stomaty. The purpose of the work is to determine the pathophysiological mechanisms and criterion-significant indicators of inability to sew anastomosis. In the study of this issue, an analysis of the immediate results of treatment of 74 patients, which was a test group, which operative treatment was performed in a radical volume. Patients were divided into two groups according to the anastomosis failure: Group Іa - patients who had been operated on for gastric cancer and who had anastomosis failure - 16 patients, II group 58 patients - who had been surgically inoperative and had not been diagnosed insolvency The patients of each group were divided into four subgroups, depending on the presence of instability of microsatellites in the locuses of the VAT-25, VAT-26. The presence of Streptococcus Bovis stomach cancer patients may be an early marker of disease progression. The leading metabolic profile of microbiocenosis in the development of stomach cancer is the significant accumulation of biogenic amines. The analysis of the results of the study shows that the failure of anastomosis in patients with gastric cancer is accompanied by profound disorders of the metabolism of connective tissue and is confirmed by increased activity of elastase, collagenolithic activity of blood serum and its content of glycosaminoglycans. The activity of elastase and glycosaminoglycans may be a prognostic criterion for insufficiency of seams in the course of treatment.


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1. Berdov B.A. Combined treatment of stomach cancer with preoperative and intraoperative irradiation. Berdov., V.Yu. Skoropad., K.V. Pakhomenko [et al.] // Prakt. oncology. – 2001. – No. 33. – P. 35–44.
2. Davydov M.I. Modern strategy of surgical treatment of stomach cancer / M.I. Davydov, M.D. Ter-Ovanesov // Modern. Oncol. – 2010. – 3 1. – P. 4–10.
3. Dukhanina E.A. Comparative analysis of the isolation of the metastatic marker S100A4 by immune and tumor cells / E.A. Dukhanin, T.I. Lukyanova, E.A. Romanova [and others] // Bulletin of Experimental Biology and Medicine. – 2008. – T.145, No. 1. – P.85–87.
4. Martling A.L. Stockholm colorectal cancer study group. The Stockholm II trial. Preoperative radiotherapy in rectal carcinoma. Long-term follow-up of a population based study / A.L. Martling, T. Holm, H. Johansson et al. // Cancer. – 2001. – Vol. 92. – P. 896–902.
5. Yurchenko A.A. Clinical significance of some tissue markers of metastasis in stomach cancer: the dissertation Author's abstract on scientific degree competition kmn – M. – 2007.
6. Gavrilov V.B., Lobko N.F., Konev S.V. Determination of tyrosine and tryptophan-containing peptides in blood plasma by absorption in the UV region of the spectrum, Klin. lab. diag. – 2004. – No. 3. – P. 12-16.
7. Bressan A., Marini L., Michelotto M. Risk factors including the presence of inflammation at the resection margins for colorectal anastomotic stenosis following surgery for diverticular disease. // Colorectal Dis. 2018 Apr 28. doi: 10.1111/codi.14240. [Epub ahead of print].
8. Desantis M., Bernard J.L., Casanova V. Morbidity, mortality, and oncological outcomes of 401 consecutive cytoreductive procedures with hyperthermic intraperitoneal chemotherapy (HIPEC). // Langenbecks Arch Surg. – 2015. – T.400. – P. 37–48.
9. Bartlett E.K., Meise C., Roses R.E. Morbidity and mortality of cytoreduction with intraperitoneal chemotherapy: outcomes from the ACS NSQIP database. // Ann Surg Oncol. – 2014. – T.21. – P.1494–500.
10. Levine E.A., Stewart J.H., Shen P., Russell G.B. Intraperitoneal chemotherapy for peritoneal surface malignancy: experience with 1000 patients. // J Am Coll Surg. – 2014. – T.218. – P.573–585.
11. Collins, M.J., Li, X., Lv, W., Yang, C., Protack, C.D., Muto, A. et al. Therapeutic strategies to combat neointimal hyperplasia in vascular grafts. // Expert Rev Cardiovasc Ther. – 2012. - №10. – Р. 635–647.
12. Jain, M., Singh, A., Singh, V., and Barthwal, M.K. Involvement of interleukin-1 receptor-associated kinase-1 in vascular smooth muscle cell proliferation and neointimal formation after rat carotid injury // Arterioscler Thromb Vasc Biol. – 2015. -№ 35. – Р. 1445–1455
13. Sato A., Kawamoto S., Watanabe M. A novel biodegradable external mesh stent improved long-term patency of vein grafts by inhibiting intimal-medial hyperplasia in an experimental canine model. // Gen Thorac Cardiovasc Surg. – 2016. – T. 64. – P. 1–9.
14. Whitbeck M.G. and Applegate, R.J. Second generation drug-eluting stents: a review of the everolimus-eluting stents: a review of the everolimus-eluting platform.// Clin Med Insights Cardiol. – 2013. – T. 7. – P. 115–126.
15. Ghilagavathi, G. and Viju, S. Silk as a suture material. in: A. Basu (Ed.) Advances in silk science and technology. // Woodhead Cambridge. – 2015. – P. 220–232.
16. Seedial S.M., Ghosh S., Saunders R.S. Local drug delivery to prevent restenosis. // J Vasc Surg. – 2013. – T. 57. – P. 1403–1414.
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