GALECTIN-3 AS A MARKER OF MYOCARDIAL FUNCTION IN MEN AGED 40-60 YEARS WITHOUT CARDIOVASCULAR PATHOLOGY, CARRIERS OF POLYMORPHIC GENES AT1R

  • V.O. Ruzhanska National Pirogov Memorial Medical University, Vinnytsia
  • V.G. Sivak National Pirogov Memorial Medical University, Vinnytsia
  • M.S. Lozinska National Pirogov Memorial Medical University, Vinnytsia
  • V.М. Zhebel National Pirogov Memorial Medical University, Vinnytsia
Keywords: polymorphism of the gene of the angiotensin II receptor type (AT1R), galectin-3, brain natriuretic peptide, arterial pressure.

Abstract

The concentrations of galectin-3 and BNP, central and systemic hemodynamics, structural and functional heart parameters in male carriers of polymorphic AT1R genes without cardiovascular pathology (n = 79) living in Podillya region were studied. Genotyping of the AT1R gene was carried out using a polymerase chain reaction. The level of galectin-3 and BNP was determined by the method of enzyme immunoassay. It was found that the A1166A genotype dominated in practically healthy men of Podilly region. Nevertheless, the level of galectin-3 and BNP in the studied population did not significantly depend on the carriage of a specific variant of the AT1R gene.

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Published
2018-03-20
How to Cite
Ruzhanska, V., Sivak, V., Lozinska, M., & Zhebel, V. (2018). GALECTIN-3 AS A MARKER OF MYOCARDIAL FUNCTION IN MEN AGED 40-60 YEARS WITHOUT CARDIOVASCULAR PATHOLOGY, CARRIERS OF POLYMORPHIC GENES AT1R. The Medical and Ecological Problems, 22(1-2), 38-42. https://doi.org/10.31718/mep.2018.22.1-2.08